Tuesday, December 24, 2013

IRON STORAGE DISORDERS

The amount of iron stored by the body is measured indirectly with measuring the ferritin levels. Ferritin is a body protein that is used to store iron. There are some tests that help us to evaluate the body’s iron stores such as ferritin test, iron binding capacity test ect.
Normal results for a ferritn test are 12-300 nanograms per milliliter of blood for males and 12-150 ng/ml for females.
High levels of ferritin can be indicative for hemochromatosis. This is genetic disorder in which there is excessive accumulation of iron in the body. There is  problem is with the absorption of iron from the intestines which is greater than the amount needed to replace losses. Normaly the body cannot increase iron excretion there for the absorbed iron accumulates in the body. The excess iron deposits in the heart, joints, testicles, liver and causes damage to these organs. So the sign and symptoms of hemochromatosis came from these organs. Women develop sign and symptoms 10 years later then man, because they lose the iron thanks to menstruation. Sign and symptoms of hemochromatosis are: fatigue, joint pains, heart failure, diabetes mellitus, liver cirrhosis, sexual dysfunction and  darkening of skin. Also some chronic inflammatory conditions such as liver disease rheumatoid arthritis or some types o f cancer can be caused  from high ferritin levels.

When  the levels of ferritin are low we have iron deficiency. In these condition the body cannot produce sufficient  levels of hemoglobin (component of red cells that carries the oxygen)  and we have anemia. Sign and symptoms of anemia are: fast heartbeat, dizziness, fatigue, shortness of breath and pale skin.

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